Expanded Stem Cell Therapy as a Possible Alternative to Shoulder Surgery: MRI-Confirmed Healing of Rotator Cuff Tear — A Case Report

30 January 202630 January 2026 by Dr. Hassan Mubark

Originally published as:
Expanded Stem Cell Therapy as a Possible Alternative to Shoulder Surgery: MRI-Confirmed Healing of Rotator Cuff Tear – A Case Report
Kosmos Publishers, 2026

Author: Dr. Hassan Mubark
Original publication: Kosmos Publishers
Original URL: https://kosmospublishers.org/expanded-stem-cell-therapy-as-a-possible-alternative-to-shoulder-surgery-mri-confirmed-healing-of-rotator-cuff-tear-a-case-report-2/

**^{Hassan Mubark*}**

Rheumatologist, Institution: Auckland Regenerative Clinic, Ormiston Specialist Centre, 125 Ormiston Road, Flat Bush, Auckland 2019, New Zealand

Received Date: December 12, 2025; Accepted Date: January 10, 2026; Published Date: January 22, 2026;

^*Corresponding author: Hassan Mubark, Rheumatologist, Institution: Auckland Regenerative Clinic, Ormiston Specialist Centre, 125 Ormiston Road, Flat Bush, Auckland 2019, New Zealand. Phone: +64 9 2713305; Mobile: +64 21843513; Fax: +64 9 2770769; Email: drhassanmubark@gmail.com

DOI: 10.37722/AOASM.2026102

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Abstract

Background: Partial-thickness supraspinatus tears and long-head biceps tendon pathology, including tenosynovitis, are common causes of shoulder pain and functional impairment. When conservative management fails, arthroscopic surgery is frequently recommended. Biologic therapies—particularly adipose-derived mesenchymal stem cells (AD-MSCs)—are emerging as minimally invasive regenerative alternatives.

Case: A 50-year-old male business development manager sustained an acute left-shoulder injury while twisting with a 10-kg lawn-mower catcher. He developed significant functional limitations, including restricted shoulder elevation, inability to reach behind his back, nocturnal pain, and reduced work capacity. Conservative treatments—including osteopathy, acupuncture, and corticosteroid injection—provided only transient relief. Baseline MRI demonstrated a 10-mm articular-surface partial-thickness supraspinatus tear, long-head biceps tenosynovitis, and subacromial bursitis. Surgical repair was scheduled.

The patient underwent culture-expanded autologous adipose-derived MSC therapy. A structured rehabilitation program was implemented, consisting of light exercises during the first two weeks followed by progressive strengthening. At 14-week follow-up, the patient reported approximately 80% clinical improvement, returned to full work duties after only six days off, and cancelled the planned surgery. Follow-up MRI demonstrated healing of the supraspinatus tear with resolution of biceps tenosynovitis and subacromial bursitis.

Conclusion: This case demonstrates clinically meaningful improvement with MRI-documented healing of a partial-thickness supraspinatus tear, long-head biceps tendinitis, and subacromial bursitis following culture-expanded AD-MSC therapy, effectively avoiding shoulder surgery. Controlled studies are warranted to further evaluate efficacy and reproducibility.

Keywords: Adipose-derived mesenchymal stem cells; culture-expanded MSCs; partial-thickness rotator cuff tear; supraspinatus tendon; long-head biceps tenosynovitis; subacromial bursitis; orthobiologics; magnetic resonance imaging; regenerative medicine; shoulder surgery avoidance.

Introduction

Rotator cuff tears (RCTs) are common musculoskeletal conditions whose prevalence increases with advancing age, often reflecting progressive tendon degeneration rather than acute injury alone [1]. Many RCTs remain asymptomatic; however, when symptoms develop, patients may experience significant shoulder pain, weakness, and functional limitation affecting daily activities and quality of life [2]. Conventional non-operative treatments, including physiotherapy and subacromial corticosteroid injections, can provide symptomatic relief but do not address the underlying tendon pathology and often yield only short-term benefits [3].

Importantly, current non-surgical strategies are largely palliative, targeting pain modulation and functional compensation rather than restoring tendon structure or reversing degenerative changes. As a result, symptom recurrence and progressive tendon deterioration are common, particularly in chronic and biologically compromised tears.

Chronic rotator cuff tears demonstrate limited intrinsic healing capacity, making spontaneous structural repair unlikely and frequently leading to recommendations for surgical intervention in symptomatic cases [4]. Despite advances in surgical techniques, re-tear rates and incomplete tendon–bone healing remain substantial challenges, particularly in degenerative and chronic tears, and surgical outcomes may be suboptimal in older patients or those with poor tendon quality [5].

These limitations have driven increasing interest in regenerative medicine strategies, including platelet-rich plasma (PRP) and mesenchymal stem cell (MSC)–based therapies, aimed at enhancing biological tendon repair rather than relying solely on mechanical fixation or symptom control [6]. Preclinical studies have demonstrated that MSCs can promote tendon regeneration through paracrine signaling, modulation of inflammation, and improved tendon–bone interface healing [7]. Emerging clinical evidence suggests that stem cell–based therapies may improve pain, function, and structural healing in selected patients with rotator cuff tears, offering a promising biologic alternative or adjunct to surgical repair [8].

Rotator cuff tears are associated with a biologically compromised tendon–bone interface and reduced local regenerative capacity. Reduced concentrations of mesenchymal stem cells at the greater tuberosity have been demonstrated in symptomatic rotator cuff tears, suggesting an intrinsic impairment in tendon healing [9]. This has led to increasing interest in biologic augmentation, with clinical studies showing improved pain and functional outcomes following autologous bone marrow–derived cell therapies [10]. Randomized controlled trial data further support the potential benefit of bone marrow concentrate, alone or combined with platelet products, as a non-surgical regenerative treatment for rotator cuff tears [11].

Case Report

Patient and Injury

A 50-year-old right-handed business development manager injured his left shoulder when twisting with a 10-kg lawn-mower catcher, hearing an audible snap and fearing dislocation.

Symptoms

• Inability to lift arm above 90°
• Difficulty reaching behind his back
• Severe nocturnal pain
• Pain with lifting and reduced work capacity

Baseline MRI Findings

• 10-mm supraspinatus articular-surface partial-thickness tear
• Long-head biceps tenosynovitis
• Subacromial bursitis
• Mild glenohumeral joint (GHJ) and acromioclavicular (ACJ) osteoarthritis, labral fraying, loose body

Intervention: Culture-Expanded AD-MSC Therapy

Adipose tissue was harvested, and mesenchymal stem cells (MSCs) were culture-expanded using the following protocol. After obtaining informed consent, abdominal subcutaneous adipose tissue was collected by a qualified plastic surgeon under sterile conditions. The harvested lipoaspirate was washed and enzymatically digested using collagenase (0.2 U/mL). The resulting stromal vascular fraction (SVF) was isolated by density-gradient centrifugation and subsequently plated for culture expansion. Cells were cultured in Dulbecco’s Modified Eagle Medium (DMEM) supplemented with 10% human platelet lysate (HPL) to promote MSC proliferation. The cells were expanded to approximately 90% confluency over a period of just under six weeks, after which they were cryopreserved until the scheduled treatment date.

On the day of administration, the cryopreserved cells were thawed, washed, and filtered under sterile conditions, then resuspended in Hartmann’s solution supplemented with 10% HPL and prepared in syringes for injection. Cell counts were determined manually using a haemocytometer, and cell viability was assessed by trypan blue exclusion dye assay.

Ultrasound-guided injections performed:

1. Intra-articular GHJ: 50 million MSCs + platelet-rich plasma (PRP) + soluble hyaluronic acid (HA) to protect the joint and slow the progression of mild osteoarthritis
2. Supraspinatus tendon substance directly into the tear: 25 million MSCs + PRP (fig1) and vid 1
3. Subacromial bursa: 25 million MSCs + PRP
4. Biceps tendon sheath: 25 million MSCs + PRP
5. Subscapularis tendon: 25 million MSCs + PRP

Video 1 demonstrating stem cells into the supraspinatus tendon tear under ultrasound guidance. (click here to watch)

Outcomes

Clinical Outcomes at 14 Weeks

A structured rehabilitation program was implemented, consisting of light exercises during the first two weeks followed by progressive strengthening

• ~80% pain and function improvement
• Returned to full work duties
• Surgery was cancelled

MRI Findings at 14 weeks (Fig.2)

• No visible supraspinatus defect
• Minimal residual insertional interstitial signal
• Resolution of subacromial bursitis
• Resolution of long-head biceps tenosynovitis with normal tendon continuity and groove position (Fig.3)

Discussion

Rotator cuff tendons are prone to degeneration due to limited vascularity and a reduced intrinsic regenerative capacity, resulting in poor healing responses following injury and a tendency toward fibro-scar formation rather than true tendon regeneration [12]. This biological limitation underpins the high failure and re-tear rates observed with both conservative care and surgical repair, particularly in degenerative supraspinatus pathology [13].

Regenerative medicine strategies aim to biologically augment tendon repair by providing cellular and molecular signals that promote neotendon formation rather than mechanically inferior scar tissue [14]. Mesenchymal stem cells (MSCs) have emerged as a promising modality due to their paracrine activity, immunomodulatory effects, and ability to influence tenocyte differentiation and extracellular matrix remodeling [15].

In parallel, platelet-rich plasma (PRP) delivers a concentrated milieu of growth factors that support angiogenesis, cellular recruitment, and matrix synthesis, making it a logical biological adjunct for tendon healing [16]. The combined use of MSCs and PRP is hypothesised to exert synergistic effects, whereby PRP enhances stem cell viability and signaling while MSCs provide sustained regenerative cues within the damaged tendon environment [17].

In the present case, a partial-thickness supraspinatus tendon tear demonstrated both clinical improvement and radiological evidence of tendon healing following a single, ultrasound-guided, non-surgical injection of combined autologous stem cells and PRP [18]. Importantly, this regenerative response was accompanied by complete resolution of associated subacromial bursitis, suggesting that the biologic intervention addressed not only the tendon defect but also the inflammatory peritendinous milieu [19].

The resolution of subacromial bursitis is clinically relevant, as bursitis is a major contributor to pain, impingement symptoms, and functional limitation in rotator cuff disease, and its persistence often predicts poor outcomes with standard conservative therapies [20]. The ability of biologic therapy to simultaneously modulate inflammation and promote structural repair highlights a potential advantage over isolated physical therapy, corticosteroid injection, or analgesic-based approaches.

This case builds upon our previously published world-first report of complete MRI-confirmed healing of a full-thickness, retracted supraspinatus tendon tear treated non-surgically using expanded autologous adipose-derived stem cells, achieving an outcome comparable to surgical repair [21]. While the current case involves a partial-thickness tear, it reinforces the concept that biologic tendon regeneration is achievable across the rotator cuff disease spectrum, from early-stage partial tears to advanced full-thickness retracted pathology. Together, these cases support the evolving paradigm that selected rotator cuff tears can be biologically healed rather than mechanically repaired.

Despite the encouraging outcomes, limitations include the single-case design and the absence of histological confirmation of neotendon formation, which restricts generalisability and mechanistic certainty [12]. Nevertheless, adherence to established regulatory frameworks and biologics reporting standards strengthens the clinical relevance of these findings [20].

Conclusion

Culture-expanded AD-MSC therapy resulted in marked clinical improvement and MRI-confirmed healing of the supraspinatus tear and long-head biceps pathology, thereby avoiding the need for surgery. Larger, controlled clinical studies are required to validate and extend these promising findings.

Patient Consent: Written informed consent was obtained for publication.

Acknowledgement: The authors thank the patient for consenting to share his case in support of advancing regenerative science and acknowledge the radiologist for providing detailed reports and high-quality pre- and post-treatment MRI images.

References

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3.Blair B, Rokito AS, Cuomo F, Jarolem K, Zuckerman JD. Efficacy of injections of corticosteroids for subacromial impingement syndrome. J Bone Joint Surg Am. 1996;78(11):1685–1689.
Safran O, Schroeder J, Bloom R, Weil Y, Milgrom C. Natural history of nonoperatively treated symptomatic rotator cuff tears in patients 60 years old or younger. Am J Sports Med. 2011 Apr;39(4):710–4.
5.Han L, Fang WL, Jin B, et al. Enhancement of tendon–bone healing after rotator cuff injuries using combined therapy with mesenchymal stem cells and platelet-rich plasma. Eur Rev Med Pharmacol Sci. 2019;23(20):9075–9084.
6.Kim SJ, Song DH, Park JW, et al. Effect of bone marrow aspirate concentrate–platelet-rich plasma on tendon-derived stem cells and rotator cuff tendon tear. Cell Transplant. 2017;26(5):867–878.
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Hernigou P, Merouse G, Duffiet P, Chevallier N, Rouard H. Reduced levels of mesenchymal stem cells at the tendon–bone interface tuberosity in patients with symptomatic rotator cuff tear. Int Orthop. 2015 Mar;39(6):1219–1225.
Centeno CJ, Al-Sayegh H, Bashir J, Goodyear S, Freeman MD. A prospective multi-site registry study of a specific protocol of autologous bone marrow concentrate for the treatment of shoulder rotator cuff tears and osteoarthritis. Pain Res Manag. 2015;8:269–276.
Centeno CJ, Fausel Z, Stemper I, et al. A randomized controlled trial of the treatment of rotator cuff tears with bone marrow concentrate and platelet products compared to exercise therapy: a midterm analysis. Stem Cells Int. 2020;2020:5962354.
Harrison-Brown M, Scholes C, Hafsi K, et al. Efficacy and safety of culture-expanded mesenchymal stem/stromal cells for the treatment of knee osteoarthritis: a systematic review protocol. J Orthop Surg Res. 2019;14:34.
Centeno CJ, Al-Sayegh H, Freeman MD, et al. A multi-center analysis of adverse events among two thousand three hundred seventy-two adult patients undergoing autologous stem cell therapy for orthopaedic conditions. Int Orthop. 2016;40(8):1755–1765.
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Tatsis D, Vasalou V, etal. The combined use of platelet-rich plasma and adipose-derived mesenchymal stem cells promotes healing: a review of experimental models and future perspectives. Biomolecules. 2021;11(10):1403.
Kim YS, Sung CH, Chung SH, Kwak SJ, Koh YG. Does an injection of mesenchymal stem cells loaded in fibrin glue influence rotator cuff repair outcomes? Am J Sports Med. 2017;45(9):2010–2018.
Jo CH, Lee SY, Yoon KS, et al. Intratendinous injection of autologous adipose tissue-derived mesenchymal stem cells for the treatment of rotator cuff disease: a first-in-human trial. Stem Cells. 2018;36(9):1441–1450.
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Mubark H, et al. MRI-documented tendon healing following expanded autologous adipose-derived cell therapy for rotator cuff pathology: a clinical case report. Biologic Orthop J. 2023;1(1):7–10.

Author note: This article was authored by Dr. Hassan Mubark, who is also the clinical director of Regenerative Clinic NZ. Republishing is permitted by the author.

Medical Disclaimer: This article is a case report and is provided for educational purposes only. It does not constitute medical advice. Individual results may vary. Patients should consult a qualified medical professional before pursuing treatment.

Effective Solutions for Sore Joints: Pain Relief and Treatment Options

7 August 20257 August 2025 by gherkinmedia

Are You Struggling with Sore Joints?

Sore joints are a common complaint that can affect people of all ages and lifestyles. Whether it’s knee pain after exercise, stiff hands in the morning, or joint inflammation caused by a health condition like rheumatoid arthritis or osteoarthritis, the pain and swelling can significantly reduce your quality of life.

At Auckland Regenerative Clinic, Dr. Hassan Mubark specialises in non-surgical, regenerative treatments designed to relieve joint pain, restore function, and improve joint health without the need for invasive surgery.

Understanding Sore Joints and Joint Pain

Joint pain occurs when any part of a joint — including bones, cartilage, tendons, ligaments, or joint fluid — becomes inflamed, injured, or worn down.

It may present as:

Joint stiffness (especially in the morning or after rest)
Swelling or warmth in the affected joint
Severe pain that worsens with activity or weight-bearing
Pain in common joints such as knees, hips, hands, shoulders, and the big toe

Joint pain and swelling can affect more than one joint at a time, including elbows, wrists, and knees.

Most people experience joint discomfort as a result of overuse, inflammatory arthritis, or autoimmune conditions where the immune system mistakenly attacks healthy joint tissue.

Common Causes of Joint Pain

Understanding the underlying condition behind sore joints is key to successful treatment. There are more than 200 different kinds of rheumatic conditions, including arthritis, gout, and lupus.

The most common causes include:

The most common types of arthritis are osteoarthritis and rheumatoid arthritis.
- Osteoarthritis: Wear-and-tear breakdown of cartilage between bones, commonly affecting the thigh bone and knee joints.
- Rheumatoid arthritis: An autoimmune condition causing joint inflammation in both large and small joints.
Gout: Often impacts the big toe due to excess uric acid crystals.
Injury or overuse: Damaged tendons, ligaments, or muscles around the joint.
Infections or reactions to certain foods that trigger joint swelling.
Reactive arthritis may occur following a bacterial infection.

Acute joint pain usually comes on quickly and does not usually last long, while chronic joint pain may result from a rheumatic condition. At Auckland Regenerative, we offer diagnostics such as blood tests and imaging to pinpoint the cause and create a tailored joint pain treatment plan.

How to Relieve Joint Pain and Discomfort

To ease joint pain, a combination of approaches is often most effective:

Rest and reduce strain on painful joints.
Apply a hot water bottle or heating pad for stiffness or use an ice pack (even frozen peas) to reduce inflammation.
Engage in physical therapy to improve mobility, posture, and strength.
Use nonsteroidal anti-inflammatory drugs (NSAIDs) or pain-relief medication.
Adopt relaxation techniques like deep breathing and mindfulness.
Regular exercise is important to help you keep fit, independent, and mobile. Gentle exercises like swimming, aqua aerobics, tai chi, cycling, or walking can help relieve joint pain.
Losing weight can significantly relieve pressure on the joints, especially the knees and hips.

Managing Pain and Swelling Effectively

Managing pain and swelling involves a careful balance of therapeutic interventions:

Hyaluronic acid injections: Naturally lubricate joints and reduce friction
Steroid injections: Used occasionally to bring down acute inflammation in swollen joints
Physical activity: Low-impact exercises like swimming or cycling keep muscles strong without stressing joints
Occupational therapist guidance: Helps adapt daily activities to minimise stress on affected joints

If the pain in your joints is getting worse or spreading to other joints, early treatment can prevent progression and disability.

When to See a Specialist in Auckland

If your joint pain is interfering with your daily activities, worsening over time, or accompanied by other symptoms like fatigue, fever, or weight loss, it’s time to seek help.

Dr. Hassan Mubark, an internationally recognised rheumatologist and regenerative medicine specialist, leads the team at Auckland Regenerative Clinic. With over 30 years of experience and award-winning results, he provides evidence-based, patient-centred care for those struggling with persistent or unexplained joint discomfort.

Regenerative Treatment Options at Auckland Regenerative

We specialise in non-surgical regenerative treatments to relieve pain and support tissue regeneration in sore or painful areas. Our most popular treatment options include:

1. Autologous Conditioned Plasma (ACP)

This comprises drawing your blood, spinning it to separate high number of platelets and growth factors to maximise the benefit, and injecting them back into the affected joint or tendons to promote healing. PRP is ideal for knee and hip pain, tendon injuries, and mild to moderate stage osteoarthritis and tendon tear (s).

2. Platelet-Rich Plasma (PRP) Therapy

This involves drawing your blood, spinning it to isolate platelets and growth factors, and injecting them back into the affected joint to promote healing. PRP is ideal for knee, hip, & shoulder pain, tendon injuries, and early-stage osteoarthritis.

3. Bone Marrow Stem Cell Therapy (BMAC)

Extracted from your hip bone, these stem cells are reinjected on the same day to stimulate repair and reduce pain in joints with degenerative changes.

4. Purified Expanded Stem Cell Therapy (PESC)

We culture your own fat-derived stem cells over several weeks to dramatically increase their number before reintroducing them to painful joints. This therapy is ideal for advanced joint inflammation and severe pain.

5. Hyaluronic Acid Injections

For those with joint stiffness or poor lubrication in the joint fluid, HA injections restore glide and comfort, particularly in knee joints.

Associated Symptoms and Contributing Factors

Joint issues often come with other symptoms that should not be ignored, including:

Fatigue
Morning stiffness
Warmth or redness around the painful area
Reduced range of motion
Instability or a “locking” sensation in the joint

In some cases, health conditions like lupus, thyroid disorders, or infections may also affect the joints. Proper testing and a full clinical history are essential for the right diagnosis and management.

Holistic Strategies for Joint Health

Maintaining good joint health involves:

Staying physically active with guided exercise
Managing weight
Following an anti-inflammatory diet
Avoiding repetitive stress or poor posture
Consulting a healthcare provider regularly

Occupational therapists and physiotherapists can work with you to adjust your activities while reducing pain and improving strength.

Conclusion

Joint pain doesn’t have to control your life. With accurate diagnosis and advanced regenerative options from Dr. Hassan Mubark at Auckland Regenerative Clinic, you can find effective relief and long-term improvement. We offer personalised treatment plans that focus on healing—not just symptom suppression.

FAQs

How can I stop my joints from aching?

You can relieve aching joints through rest, weight management, physical therapy, ice or heat therapy, and regenerative treatments like PRP, ACP or stem cell therapy.

Which deficiency causes joint pain?

Deficiencies in vitamin D, magnesium, and omega-3 fatty acids are commonly linked to joint pain and inflammation.

Is joint pain always arthritis?

No. Joint pain can also be caused by injuries, infections, overuse, or other health conditions. Proper evaluation is key.

Are hyaluronic acid injections effective?

Yes. Hyaluronic acid injections can improve joint lubrication, reduce pain, and delay the need for surgery in conditions like knee osteoarthritis.

When should I see a doctor for joint pain?

If you have persistent joint pain, swelling, or symptoms that impact daily life, consult a doctor or rheumatologist promptly.

Book a Consultation with Auckland’s Best Rheumatologist

Don’t let sore joints slow you down.

Book a consultation with Dr Hassan Mubark at Auckland Regenerative Clinic today and discover your personalised, non-surgical treatment plan.

Success Story: From Knee Pain to Ballroom Bliss – Beverley’s Remarkable Comeback with Regenerative Therapy

7 August 2025 by gherkinmedia

At Auckland Regenerative Clinic, we are proud to share the inspiring journey of our patient, Beverley De Bont, a 79-year-old competitive ballroom dancer whose passion for movement was nearly extinguished by chronic knee pain—until regenerative medicine helped turn her life around.

Featured in New Zealand Woman’s Weekly (Issue 28, 2025) “Ballroom Blitz: The Dancers Who Won’t Quit”, Beverley’s story is a testament to what’s possible when advanced science meets a strong spirit.

A Life Interrupted by Pain

For decades, Beverley found joy and purpose gliding across the dance floor in foxtrots, waltzes, and elegant routines. But in 2020, debilitating knee pain threatened to end her dancing career and the lifestyle she loved.

“I kept feeling awful, thinking, ‘What am I going to do with my life?’” she recalls. When her son Daniel suggested stem cell therapy, Beverley made the pivotal decision to consult Dr Hassan Mubark, a specialist in regenerative medicine at Auckland Regenerative Clinic.

A Turning Point with Stem Cell Therapy

Following a comprehensive assessment, Dr Mubark determined that Beverley was a suitable candidate for Purified Expanded Stem Cell Therapy, a non-surgical procedure designed to restore joint health using a patient’s own cells. In November 2020, she received treatment on both knees—and her recovery was nothing short of remarkable.

“After the procedure, I walked out,” says Beverley. “It was like I got my life back.”

Today, five years on, Beverley continues to dance competitively and remains pain-free. Her success story highlights the lasting benefits of stem cell therapy and how regenerative medicine can restore mobility, independence, and joy.

Leading by Example

Now teaching seniors how to dance, Beverley inspires others—especially those in pain—to take that first step toward healing. Her story is a powerful reminder that age doesn’t define your future, and pain doesn’t have to be permanent.

“This milestone highlights the enduring results of regenerative therapy,” says Dr Mubark. “We’re proud to have played a role in Beverley’s journey to renewed wellness and continued success.”

Thinking About Stem Cell Therapy?

If you’re struggling with joint pain or considering alternatives to surgery, book a consultation with Dr Hassan Mubark at Auckland Regenerative Clinic. Discover how regenerative medicine can help you regain movement and improve your quality of life.

Understanding the Science Behind How PRP (Plasma) Treatment Therapy Works

30 May 202512 July 2024 by Auckland Regenerative

Platelet Rich Plasma therapy, known as PRP (plasma) therapy, is an innovative and rapidly growing approach in regenerative medicine, especially popular for treating various injuries and conditions. By harnessing the body’s own healing mechanisms, PRP therapy can promote tissue regeneration and reduce pain, making it a preferred choice for many patients.

What is PRP Therapy?

PRP therapy entails the use of Platelet Rich Plasma (PRP) derived from the patient’s blood. This concentrated form of plasma is rich in platelets and growth factors, that play an important role in the healing process. PRP injections are commonly used to treat conditions such as chronic tendon injuries, muscle injuries, knee sprains,meniscus or labral tear, joint osteoarthritis (wear and tear) and even hair loss.

The Biological Basis of PRP Therapy

The effectiveness of PRP therapy lies in its biological basis. Platelets, a type of blood cell, are essential for blood clot formation, blood clotting, and wound healing. When concentrated into PRP, they release proteins called growth factors that activate cell repair and regeneration. These growth factors and other proteins found in PRP help accelerate the healing of damaged tissues.

The Process of Creating Platelet Rich Plasma

Creating PRP involves drawing a blood sample directly from the patient and processing it in a centrifuge to separate the targeted platelets from other blood cells, including white blood cells and red blood cells. This process subsequently concentrates the platelets and growth factors into a small volume of plasma. The resulting pure PRP is then injected directly into the injury site, often under ultrasound guidance, to ensure precision.

How PRP Promotes Healing and Tissue Regeneration

Once injected, the concentrated platelets in PRP release proteins called growth factors directly at the injury site. These growth factors enhance the body’s natural healing process by promoting cell proliferation, reducing inflammation, and stimulating the production of new tissue. PRP therapy can help repair torn tendons, reduce pain, stiffness and improve ranage of motions in conditions like knee/hip/shoulder/elbow/ankle osteoarthritis.

Applications of PRP Therapy at Auckland Regenerative Clinic

At Auckland Regenerative Clinic, PRP therapy is used to treat a variety of conditions, including acute sports injuries, chronic tendon injuries, osteoarthritis, frozen shoulder, labral and meniscus tear and musculoskeletal conditions. The clinic’s specialists employ advanced techniques, such as ultrasound guidance, to ensure accurate PRP injections.

Clinical Evidence Supporting PRP Therapy

Clinical studies have shown favourable results for PRP therapy in treating various conditions. Research indicates that PRP can significantly improve function whilst reducing pain and stiffness in patients with various joints, osteoarthritis, chronic tendon injuries (tendinitis and tear), and other musculoskeletal issues. The therapy also accelerates healing in professional athletes and those recovering from surgery.

Frequently Asked Questions

Q1. What is PRP therapy used for?

A1. PRP therapy treats a range of conditions, including chronic tendon injuries, muscle injuries, knee and various ther joints osteoarthritis, and acute sports injuries.

Q2. How long does it take to see results from PRP therapy?

A2. Results from PRP therapy can vary, but many patients start to notice improvements within a week to several weeks of treatment, depending on the tissue damage you have.

Q3. Are there any side effects or risks associated with PRP therapy?

A3. PRP therapy is considered safe for patients, as it uses their own blood thus, rejection is not possible. However, some may experience transient ( a couple of days) increased pain and swelling at the PRP injection site, but we do our best to reduce the pain by using local anaesthetic.

Q4. Are PRP injections worth the money?

A4. PRP injections can be a worthwhile investment for those seeking non-surgical alternatives to traditional treatments, particularly for conditions that have not responded well to other therapies.

PRP treatment therapy offers a promising and effective approach to healing and tissue regeneration, utilising the body’s natural processes. With growing clinical evidence supporting its efficacy, PRP therapy remains a valuable option for patients seeking relief from various injuries, osteoarthritis and musculoskeletal conditions.

If you’re struggling with chronic pain, sports injuries, osteoarthritis or other musculoskeletal issues, consider PRP therapy at Auckland Regenerative Clinic. Dr Hassan Mubark and his expert team specialise in advanced PRP treatments tailored to your specific needs. Contact us today to schedule a consultation and learn how PRP therapy can help you achieve better health and improved function. Visit our website or call us directly to take the first step towards a pain-free or pain diminishing life.

Understanding Rheumatology: Symptoms, Treatments, and Managing Chronic Joint Conditions

30 May 202511 December 2023 by Auckland Regenerative

Imagine regaining control over your life by understanding and managing the chronic joint conditions that have hindered your daily activities. Rheumatic diseases, including those in the field of rheumatology, can be debilitating, but with the right knowledge and treatment, you can take charge of your health, alleviate pain, and improve your overall well-being.

Key Takeaways

Rheumatology is the study and management of joint, muscle, and connective tissue diseases.
Treatment options for rheumatic diseases include medications, physical therapy/exercise, alternative therapies such as acupuncture or dietary modifications.
Maintaining a healthy lifestyle, including rest and proper nutrition, can help manage symptoms. Innovative treatments like stem cell therapy may provide revolutionary relief from pain associated with these conditions.

Rheumatology Explained

Rheumatology studies disorders affecting the joints, muscles, and connective tissues, which are key in managing arthritis and other rheumatic diseases. While a family history of rheumatoid arthritis may be problematic for many, gaining knowledge about these conditions can help prevent likely complications. Some common rheumatic conditions include:

Rheumatoid arthritis
Psoriatic arthritis
Ankylosing spondylitis
Osteoarthritis
Gout
Lupus (SLE)
Scleroderma
Complex regional pain syndrome
Fibromyalgia

Treating rheumatic diseases requires a multi-faceted approach, which may include medications, physical therapy, exercise, and alternative therapies. Managing symptoms of these diseases, such as rheumatoid arthritis, involves maintaining a healthy lifestyle, implementing joint protection measures, and providing emotional support and coping mechanisms.

Role of Rheumatologists

Rheumatologists are specialised physicians trained to diagnose and treat rheumatic diseases like rheumatoid arthritis. They work closely with patients to:

Develop a treatment regime to meet their individual needs and concerns
Effectively manage conditions like rheumatoid arthritis
Provide ongoing care

This expertise allows them to effectively manage conditions like rheumatoid arthritis and provide ongoing care.

The relationship between a rheumatologist and a patient is essential, ensuring the best possible care and treatment outcomes. Most individuals with rheumatoid arthritis will require ongoing treatment to manage symptoms and prevent permanent joint damage, making the expertise of a rheumatologist invaluable.

Common Rheumatic Conditions

Rheumatic conditions, including autoimmune disease, can manifest in various forms, with osteoarthritis, rheumatoid arthritis, gout, and lupus being some of the most common. Rheumatoid arthritis, for instance, is a chronic condition characterised by fatigue, pain, swelling, and joint deformity. Diagnosing this condition typically involves blood tests that measure levels of proteins and antibodies and indicators of inflammation.

Flare-up periods of increased disease activity are common in rheumatoid arthritis. Rheumatoid arthritis appears with inflammation potentially affecting other organs and even causing the appearance of rheumatoid nodules. When pain is severe or joint deformities are disabling, surgery may be necessary to treat rheumatic diseases.

Identifying Symptoms of Rheumatic Diseases

Symptoms of rheumatic diseases are diverse, typically involving joint pain, stiffness, inflammation, swelling, fatigue, and weakness. Early detection of these symptoms is key for effectively treating and managing people with rheumatoid arthritis. Risk factors for developing rheumatoid arthritis include female gender, family history, hormonal changes, smoking, and previous infections.

Managing symptoms of rheumatic diseases requires a combination of medical treatment and lifestyle modifications. Here are some strategies that can help:

Maintain a healthy lifestyle, including regular exercise and a balanced diet.
Practice stress management using techniques such as deep breathing and meditation.
Seek emotional support from family, friends or support groups.
Follow your prescribed medical treatment plan and attend regular check-ups with your healthcare provider.

These strategies can help improve overall health whilst reducing symptoms and making coping with the challenges of living with a chronic condition easier.

Joint Pain and Stiffness

Joint pain along with stiffness are the most common symptoms of rheumatic diseases, often worsening with inactivity or overuse. Inflammation, swelling, and joint pain can cause these symptoms, which can be alleviated through various treatment approaches.

Some ways to manage joint pain and stiffness include:

Regular physical activity
Gentle stretching exercises
Heat or cold therapy
Medications prescribed by a healthcare professional
Assistive devices, such as braces or splints

Inactivity can exacerbate joint pain and stiffness, while physical activity is beneficial in managing symptoms and improving outcomes. Consulting with a healthcare professional for an accurate diagnosis and personalised treatment plan is important.

Overuse can lead to increased joint pain and stiffness due to inflammation and joint damage. Striking a balance between rest and exercise is crucial for managing symptoms and maintaining joint health.

Inflammation and Swelling

Inflammation and swelling in joints are typical signs of rheumatic conditions, causing discomfort and limited mobility. These symptoms result from the body’s immune system mistakenly attacking its tissues, leading to joint inflammation, as seen in conditions like rheumatoid arthritis and other inflammatory arthritis conditions.

Rheumatologists utilise various methods to measure and identify inflammation and swelling, such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, rheumatoid factor, and physical examination. Timely diagnosis and treatment can help manage these symptoms and prevent further joint damage.

Fatigue and Weakness

Fatigue and weakness can accompany rheumatic diseases, impacting daily activities and overall quality of life. Causes of fatigue in rheumatic diseases may include:

Disease activity
Inflammation
Obesity
Physical inactivity
Sleep disturbance
Depression

Weakness associated with rheumatic diseases can be attributed to various factors such as:

Sleep disturbances
Fatigue
Muscle weakness
Inflammation
Pain

Addressing these factors through medical treatment and lifestyle modifications can help improve overall well-being and alleviate fatigue and weakness.

Treatment Options for Rheumatic Diseases

Treating rheumatic diseases involves a combination of medications, physical therapy, and alternative therapies aimed at managing symptoms and improving patients’ well-being. These treatments can help reduce pain, inflammation, and swelling while improving joint mobility and overall health.

The appropriate treatment approach can differ depending on the specific rheumatic condition and individual patient needs. Sometimes, combining treatments may be necessary to achieve the best results. Regardless of the treatment approach, the goal is to improve quality of life, manage symptoms and prevent permanent joint damage.

Medications

Medications for rheumatic diseases can include pain relievers, anti-inflammatory drugs, disease-modifying antirheumatic drugs (DMARDs), and biologics therapies like Humira and Enbrel. These medications can help manage pain, reduce inflammation, and alter the course of the disease, preventing flares and impeding disease progression.

Medications for rheumatic diseases may cause side effects, including:

Infections
Headaches
Nausea
Injection site redness
Allergic reactions
Fatigue
Stomach upset

Collaborating with your healthcare team to identify the most effective treatment plan and track potential side effects is critical.

Physical Therapy and Exercise

Physical therapy and regular exercise can often help improve joint function, strength, and flexibility while reducing pain and stiffness. Specific physical therapy exercises for rheumatic diseases include:

Low-impact aerobic activities such as walking, cycling, or swimming
Range of motion exercises
Stretching
Strengthening
Aerobic conditioning

In addition to improving physical health, exercise and physical therapy can help manage emotional distress associated with rheumatic diseases. Doing regular exercise and being active can significantly improve overall well-being and help manage rheumatic disease symptoms.

Alternative Therapies

Complementary therapies like acupuncture, massage, and dietary adjustments can support conventional treatments in managing rheumatic disease symptoms. Research has shown acupuncture’s effectiveness in pain reduction and inflammation control for rheumatoid arthritis patients.

Massage therapy can reduce pain and stiffness, improve joint mobility, and promote relaxation in those with rheumatic diseases. Dietary modifications, such as adopting a vegan or Mediterranean diet and abstaining from processed food and sugar, can also help manage symptoms and improve overall health.

Living with Rheumatic Diseases: Tips for Managing Symptoms

Living with rheumatic diseases involves maintaining a healthy lifestyle, protecting joints, and seeking emotional support to cope with the challenges of chronic conditions. Regular exercise, a healthy balanced diet, and stress management can improve overall health and help manage rheumatic disease symptoms.

Emotional support from friends, family, and support groups can help individuals deal with the challenges of living with rheumatic diseases. Providing tips and coping strategies, addressing mental health and wellbeing, and participating in mindfulness therapy programs can all contribute to a better quality of life for those living with these conditions.

Maintaining a Healthy Lifestyle

Good stress management, along with a sensible diet and exercise, can improve overall health and help manage rheumatic disease symptoms. Maintaining a healthy lifestyle involves:

Getting adequate sleep and rest
Consuming a balanced diet
Abstaining from smoking
Engaging in regular physical activity
Managing systemic inflammation through pharmacotherapeutic treatments and health and wellness approaches.

Along with a balanced diet, engaging in low-impact aerobic exercises, strength-building exercises, and practices such as yoga and tai chi can help improve physical condition and alleviate symptoms associated with arthritis.

Joint Protection Strategies

Joint protection strategies, such as using assistive devices and modifying daily activities, can minimise pain and prevent further joint damage. Some examples of assistive devices include:

Splints
Adaptive utensils
Assistive gadgets
Mobility devices
Grab bars

These devices can help reduce stress on the small joints and improve overall function.

Modifying daily activities can help protect joints from further damage in rheumatic conditions. Here are some strategies to consider:

Avoid repetitive movements
Utilise assistive devices
Maintain good posture
Pace activities to conserve energy

By using these strategies, you can better manage your condition and protect your joints.

Regular exercise and lifestyle modifications can further protect joints and support overall health. Some recommendations include:

Maintaining a healthy diet
Staying hydrated
Limiting alcohol intake
Quitting smoking
Incorporating omega-3 fatty acids into the diet

Following these practices can promote joint health, achieve a healthy weight, and greatly improve your overall well-being.

Emotional Support and Coping Mechanisms

Managing mental health is essential for people with rheumatic diseases, as the unpredictable nature of these conditions can take an emotional toll. Providing tips and coping strategies, addressing mental health and well-being, and participating in mindfulness therapy programs can help individuals deal with the emotional challenges associated with rheumatic diseases.

Peer support can also be beneficial in addressing the emotional challenges associated with rheumatic diseases. Talking with fellow patients who share similar experiences can provide valuable insight, understanding, and encouragement, helping individuals cope with their condition and improve their overall well-being.

Innovative Rheumatology Treatments: Stem Cell Therapy

Pioneering rheumatology treatments, including stem cell therapy, are under investigation by specialists such as Dr. Hassan Mubark at Auckland Regenerative Clinic. Stem cell therapy deploys adult stem cells, injected directly into the joint area, to lessen inflammation and repair tissue damage. A pain medicine specialist administers this minimally invasive treatment and holds the potential to revolutionise the treatment of rheumatic diseases.

Multiple research studies highlight the prospective advantages of stem cell therapy in managing rheumatic diseases like rheumatoid arthritis. Such findings underscore the promise of stem cell therapy as a new treatment option for some resistant rheumatic diseases as we inject the stem cells in badly involved joints to control the disease process, extending hope to those exploring alternative treatments for their condition.

Dr. Hassan Mubark’s Approach

Dr. Hassan Mubark is a highly esteemed rheumatologist with extensive knowledge in:

Rheumatoid arthritis
Psoriatic arthritis
Ankylosing spondylitis
Osteoarthritis
Gout
Lupus (SLE)
Scleroderma
Complex regional pain syndrome
Fibromyalgia

His dedication to medical research and clinical trials has been instrumental in the progress of regenerative medicine, and his expertise in rheumatology allows him to treat a variety of rheumatic diseases effectively.

Dr. Mubark’s approach to stem cell therapy is distinguished by his dedication to medical research and clinical trials, which has been instrumental in the progress of regenerative medicine. His speciality in rheumatology has allowed him to treat many patients effectively.

Patient Testimonials

Patient testimonials underscore the beneficial effects of Dr. Mubark’s stem cell therapy, demonstrating enhancements in pain relief, mobility, and overall quality of life. One case study showed symptomatic and functional improvement in severe ankle osteoarthritis due to congenital clubfeet. Another successful outcome was seen in the treatment of hand osteoarthritis in a 66-year-old woman.

Testimonials from Dr. Hassan Mubark’s patients indicate that his approach to stem cell therapy has improved their symptoms, reduced pain, and improved their quality of life. These testimonials demonstrate his expertise, care, and successful outcomes, offering hope to those seeking alternative treatments for managing their condition.

Summary

In conclusion, understanding rheumatology and the various treatment options available can empower individuals living with rheumatic diseases to take control of their health and improve their quality of life. By maintaining a healthy lifestyle, protecting joints, seeking emotional support, and exploring innovative treatments like stem cell therapy, patients can effectively manage their symptoms and live a fulfilling life despite their chronic condition.

Frequently Asked Questions

What does a rheumatologist do?

A rheumatologist is a specialised doctor with training in inflammatory (rheumatic) disease and is qualified to diagnose and treat arthritis of the bones, joints, and muscles, as well as other diseases. They commonly treat conditions such as tendon issues, muscle injuries and rare, inherited disorders.

What are the main diseases in rheumatology?

Rheumatology primarily focuses on osteoarthritis, rheumatoid arthritis, psoriatic arthritis, infectious arthritis, lupus, ankylosing spondylitis, and gout, which can cause inflammation, swelling, and joint pain.

Why am I being referred to a rheumatologist?

Your doctor may refer you to a rheumatologist if they suspect an autoimmune condition or to confirm the diagnosis of an inflammatory type of arthritis and create a management plan.

What are the symptoms of rheumatology?

Common symptoms of rheumatology include joint pain, stiffness, swelling, fatigue, and loss of appetite. There may also be warmth, redness, and tenderness around the affected joints.

How can physical therapy and exercise help individuals with rheumatic diseases?

Physical therapy and exercise can help individuals with rheumatic diseases by reducing pain and stiffness, improving joint function, and increasing strength and flexibility.

STEM CELL TREATMENT

30 May 202514 October 2022 by Auckland Regenerative

STEM CELL TREATMENT

Stem Cell Therapy in musculoskeletal and orthopaedics conditions is a new and exciting treatment that can help people with chronic conditions like degenerative arthritis and various injuries of the joint, tendon and ligaments to alleviate their symptoms and improve their quality of life. This procedure involves using stem cells, which can be harvested from your own fat or bone marrow.

WHAT CAN STEM CELL THERAPY TREAT?

The use of stem cells has been found to treat many different kinds of illnesses because it works by repairing the damage done inside your body’s organs, which causes those ailments in the first place.

The list of ailments that stem cell therapy can treat is virtually endless. From skin (like psoriasis) to musculoskeletal (like osteoarthritis) and neurological disorders such as Parkinson’s disease or Multiple sclerosis, there are many treatments available for a multitude of ailments with promising results in pre-clinical testing on humans. Our work specializes in musculoskeletal conditions with local treatment targeting the degenerative or injured area.

HOW MUCH DOES STEM CELL THERAPY COST?

Stem Cell Therapy can help with various ailments, but how much it costs depends on the type and severity of your condition. It varies depending on your location, insurance type and co-pay requirements. Still, it will generally fall between $800 for plasma injections to stimulate the internal stem cells and $17000 for expanded stem cell therapy for two areas. The prices will be cheaper when a booster dose is required.

CONSULTS

Face-to-Face – $400

Phone or Video – $300

EXPANDED STEM CELLS “INCLUDING ONE YEAR CELL STORAGE”

One joint =$15,000.00

Two joints = $17,000.00

*Repeat injection(s) = additional costs depending on the dose and number of areas to be injected

PRICES INCLUDE

Liposuction (Fat Harvesting) by the plastic surgeon.
Lab process for 8-10 weeks: purification to 95%, sterilization and culture expansion using the latest technology and high-quality consumables to produce viable and potent stem cells.
On the day of injection, blood is drawn to extract a Platelet-Rich Plasma (PRP) mixed with stem cells to stimulate them; all process is sterile.
Implantation of the stem cells under ultrasound guidance using advanced skills.
One year storage of your stem cells (cryopreserve) at the lab.
Before and aftercare of stem cell implantation.
One free follow up to patients after the implantation
Communicating with physio whenever needed.

PLASMA (PRP)

One knee =$1100

Two Knees = $1400

One hip or shoulder= $1400

Two hips or shoulder= $2400

Adding – Hyaluronic acid viscous product (HA) additional $300 per tube

HOW EXPENSIVE IS STEM CELL THERAPY?

Stem cell therapies have become very popular in recent years as people seek the latest alternative treatment for their many conditions. More types of medicines continue to be introduced every day, and all over this world, individuals reject traditional regimens with drugs or hospital visits while turning instead to Stem Cell Therapies which can help them live more healthier lives.

Stem cell therapy is a very promising treatment for many different types of conditions. The cost can range from $800 – $17000, but it’s worth the investment in your health. Plasma treatment as cheaper as $800 can stimulate your internal stem cells while higher costs for the extensive expanded stem cells harvested from your fat and processed with the latest technology at the lab for several weeks trying to repair the damaged tissues by injury or injury degenerative process.

What is stem cell therapy used for?

Stem cell therapy in our speciality we used to treat osteoarthritis, knee meniscus and labral tears of the shoulder and hip joints, tendons and ligament tears, in addition to cartilage and bone injuries.

Stem cell therapy around the world has been used to treat a variety of different ailments, including spinal cord injuries and stroke. It’s also being looked at as a potential treatment for Alzheimer’s disease because it can help control disease-causing proteins in patients’ brains called amyloid build-up, leading them to develop this condition over time if left untreated or prematurely treated with drugs that have side effects like nausea/dizziness etc.

Stem cell therapy is the treatment of choice for many different conditions. The use and benefits vary depending on what condition it’s being prescribed, but in some cases, these treatments have been proven effective at helping patients recover from serious injuries or illnesses that cause chronic pain, such as multiple sclerosis (MS).

Stimulating—or stressing- the body’s natural ability to heal itself through a process called “proliferation” might reduce inflammation-related discomfort caused by injury; promoting angiogenesis which helps create new blood vessels necessary after an accident/injury, etc. oxygen flow where there were none before.

What does stem cell therapy do?

Stem Cell Therapy is a treatment that can be used to help repair damage done by things like osteoarthritis, various injuries or chronic illness. It’s been shown in clinical trials for injuries such as broken bones, brain injury (from a stroke), burns to a scar on the skin due to personal trauma, including symptoms of arthritis, osteoporosis and even metabolic disorders including diabetes mellitus type I & II where stem cells are infused into the patient’s bloodstream through an IV at specific points during treatment, so they bypass traditional routes which allow them access directly into affected areas.

We are specialized in orthopaedic and musculoskeletal conditions, namely osteoarthritis and various injuries to cartilage, bone, meniscus, labrum, muscle, tendon and ligament.

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WHAT CAN STEM CELL THERAPY TREAT?

HOW MUCH DOES STEM CELL THERAPY COST?

CONSULTS

Face-to-Face – $400

Phone or Video – $300

EXPANDED STEM CELLS “INCLUDING ONE YEAR CELL STORAGE”

One joint =$16,000.00

Two joints = $18,000.00

*Repeat injection(s) = additional costs depending on the dose and number of areas to be injected

PRICES INCLUDE

Liposuction (Fat Harvesting) by the plastic surgeon.
Lab process for 8-10 weeks: purification to 95%, sterilization and culture expansion using the latest technology and high-quality consumables to produce viable and potent stem cells.
On the day of injection, blood is drawn to extract a Platelet-Rich Plasma (PRP) mixed with stem cells to stimulate them; all process is sterile.
Implantation of the stem cells under ultrasound guidance using advanced skills.
One year storage of your stem cells (cryopreserve) at the lab.
Before and aftercare of stem cell implantation.
One free follow up to patients after the implantation
Communicating with physio whenever needed.

PLASMA (PRP) COMBINED WITH GEL (HA)

One knee =$1200

Two Knees = $1800

One hip or shoulder= $1500

Two hips or shoulder= $2500

HOW EXPENSIVE IS STEM CELL THERAPY?

What is stem cell therapy used for?

What does stem cell therapy do?

We are specialized in orthopaedic and musculoskeletal conditions, namely osteoarthritis and various injuries to cartilage, bone, meniscus, labrum, muscle, tendon and ligament.